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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Pediatr Nephrol. 2011 Jun 22;27(8):1233–1247. doi: 10.1007/s00467-011-1938-2

Figure 5. Unilateral ureteral obstruction (UUO): a fast and reproducible model.

Figure 5

Despite some significant limitations, the UUO model reliably induces fibrosis with progressive kidney damage in all mouse strains reported to date, though the specific kinetics may vary between strains. The disease is characterized by the landmark histopathological features of chronic kidney disease that are illustrated above for the C57BL/6 strain and include: interstitial macrophage infiltration (F4/80 marker), interstitial capillary rarefaction (CD31 marker), oxidant stress markers (protein carbonyl and fatty acid-derived hydroxyoctadecadienoic [HODE] acid), interstitial myofibroblasts (αSMA marker), increased total kidney collagen and progressive decline in E-cadherin-positive tubules. These data are previously published and have been reproduced with copyright permission [14, 23] except the CD31 data (from Yamaguchi et al, unpublished). D, days after UUO surgery.