Skip to main content
. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Pediatr Nephrol. 2011 Jun 22;27(8):1233–1247. doi: 10.1007/s00467-011-1938-2

Figure 7. Col4 α−/ − hereditary nephritis model.

Figure 7

Mouse harboring a genetic mutation in the gene that encodes the glomerular basement membrane protein collagen IV alpha 3 (col4α3−/ −) develop hereditary nephritis with proteinuria and progressive renal failure. The tempo of the kidney disease is mouse strain-dependent. Compared to the asymptomatic heterozygous littermates (col4α3+/−) the mutant mice develop progressive interstitial fibrosis (shown in the Masson trichrome-stained photomicrographs), reduced tubular volume and interstitial volume expansion by matrix proteins. Data are from a study in 10-week old 129Sv/J mice that also harbor an asymptomatic heterozygous mutation in the 6 integrin gene that are reproduced from [27] with copyright permission.