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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Pediatr Nephrol. 2011 Jun 22;27(8):1233–1247. doi: 10.1007/s00467-011-1938-2

Figure 9. Chronic folic acid-induced nephropathy.

Figure 9

C57BL/6 mice given a single intraperitoneal injection of folic acid (250 mg/kg) develop acute kidney injury (shown by the serum BUN levels) but recovery is not complete. On day 14 BUN levels are still significantly elevated (64 ± 9 versus 28 ± 1 mg/dl at baseline). The kidneys show interstitial fibrosis based on computer-assisted analysis of the Masson trichrome (MT) stained interstitial area (middle graph and upper photomicrographs), accompanied by significant numbers of αSMA+ interstitial myofibroblasts (lower photomicrographs). Data are reproduced from [76] with copyright permission.