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. 2011 Aug 19;30(20):4248–4260. doi: 10.1038/emboj.2011.296

Figure 8.

Figure 8

Proposed model for PA-PLA1α- and P2Y5-mediated hair follicle development. PA-PLA1α is expressed and secreted in the developing IRS of hair follicles and produces 2-acyl-LPA from PA on the outer leaflet of the plasma membrane by hydrolyzing the acyl chain at the sn-1 position. The resulting 2-acyl-LPA activates P2Y5 in a paracrine and/or autocrine manner, eliciting TACE-dependent shedding of membrane-bound TGFα (pro-TGFα). Soluble TGFα binds to EGFR in the IRS of hair follicles. Activated/phosphorylated EGFR induces development of the IRS, which is required for proper formation of the hair shaft. Genetic deletions of these molecules (PA-PLA1α in this study and Kazantseva et al (2006), P2Y5 (Pasternack et al, 2008; Shimomura et al, 2008), TACE (Peschon et al, 1998; Hassemer et al, 2010), TGFα (Luetteke et al, 1993; Mann et al, 1993), EGFR (Luetteke et al, 1994)) result in aberrant hair formation in mice and/or humans.