FIGURE 6.

LCoR represses PCa growth in vitro and in vivo and is attenuated by Src kinase signaling. A, number of stable clones obtained from C4-2 cells overexpressing either empty vector control, LCoR, or dominant negative with a mutation in the kinase cassette Src-mut, Src, LCoR+Src mut, or LCoR+Src. LCoR-mediated repression of colony formation and potentiation by the Src mutant was significant (Student's t test, p < 0.01). B, representative photograph of the athymic nude mice bearing the xenograft of the C4-2 cell clones overexpressing LCoR and/or Src. C, tumor size of xenografts of the above-mentioned stable clones of C4-2 cells in athymic nude mice representing the growth of tumor over 6 weeks (n = 5).