FIGURE 7.

Progressive decrease in LCoR expression in vivo. A, LCoR transcript expression is progressively decreased in TRAMP mice as a function of increase in age. Prostate tissue from 16-week-old mice expresses higher LCoR mRNA than 24-week- old mice and is further decreased at 24 and 32 weeks. B, immunohistochemical analysis for LCoR expression in prostate tissue of TRAMP mice of different ages (12, 20, and 34 weeks). Experiments were conducted on five randomly selected tumor tissues from TRAMP mice in each group with similar results, and only one representative result is shown.