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Sequence alignment of OXA-58 with OXA-10, OXA-24, and OXA-48. Highlighted in red are the three conserved motifs in serine β-lactamases. The green dots indicate the residues that form the hydrophobic pocket around the conserved lysine residue. The blue dots indicate the residues that form the hydrophobic cleft in OXA-24. The secondary structures correspond to those predicted by the OXA-58 homology model.
