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CILP-2 protein is reduced in during cartilage degeneneration in a mouse model of osteoarthritis. Immunohistochemistry for CILP-2 in control (A and D) and DMM joints at 4 weeks postsurgery (B and E) and 6 weeks postsurgery (C and F) show loss of CILP-2 protein from the chondrocyte territorial and inter-territorial matrix in the deep articular cartilage zone during cartilage degeneration, visualized by loss of toluidine staining (H and I). Scale bar, 100 μm.
