Table 1.

Pharmacodynamics and pharmacokinetics of P2Y12 inhibitors in ACS.

Drug	Drug class	Half-life	Metabolism	Elimination	Onset*
Clopidogrel	Thienopyridine	6 h (pro-drug), 30 min (active metabolite)	Primarily CYP2C19	Renal and gastrointestinal	2 h
Prasugrel	Thienopyridine	2–15 h (active metabolite)	Serum esterase, CYP3A4, and CYP2B6	Renal and gastrointestinal	30 min
Ticagrelor	Cyclo-pentyl-triazolo-pyrimidine	8–9 h	Primarily CYP3A4	Hepatic and gastrointestinal	2–3 h

*Refers to loading dose administration.