Skip to main content
. Author manuscript; available in PMC: 2011 Oct 24.
Published in final edited form as: Physiol Rev. 2008 Apr;88(2):581–609. doi: 10.1152/physrev.00024.2007

Figure 4.

Figure 4

Details of the signaling pathways activated by PC. PC leads to release of agonist that activate GPCR, leading to activation of PI3K, which in turn activates AKT and P70S6K. Internalization of GPCRs involves sequential binding of β-arrestin, the clathrin adaptor (adaptor protein 2; AP-2), and clathrin. PI3K and its phosphoinositide products play a critical role in recruitment of β-arrestin GPCR complexes to endosomes. Many of these pathways converge on the mitochondria where the result in activation of the mitoKATP channel and inhibition of the MPT.