Figure 2.

Improved size measurement sensitivity and discrimination of resistive pulse sensors (a) Conical nanopore vs dynamic light scattering of a trimodal suspension of 50, 75 and 117 nm polystyrene particles. Nanopore (bar histograms) are able to distinguish between the three particle sizes in contrast dynamic light scattering gives rise to a single peak at 117 nm. Reprinted with permission from reference [41]. (b) Tuning pore size of a new elastic pore sensor improves particle sizing sensitivity of a trimodal suspension of 100, 220 and 400 nm particles by increasing the magnitude of the resistive pulse signal via reducing the particle-to-pore volume. Adapted from reference [42].