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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Int Forum Allergy Rhinol. 2011 Mar;1(2):123–127. doi: 10.1002/alr.20028

Figure 3. Base secretion across freshly excised human nasal epithelia.

Figure 3

A: The rate of HCO3− secretion in CF (n = 4) was 11.8 ± 2.4 nmol·min−1·cm−2, which is significantly lower than normal (57.2 ± 9.2 nmol·min−1·cm−2, n = 5, t-test, p = 0.004). Error bars represent SEM (standard error of the mean). * denotes a significant difference (p < 0.05).

B: Rates of base secretions plotted for individual experiments. Exposure of the mucosal surface to forskolin significantly increased base secretion in normal tissue (from 57.2 ± 9.2 nmol·min−1·cm−2 to. 66.8 ± 11.0 nmol·min−1·cm−2, p = 0.009). In CF tissue, there was no statistically significant difference in base secretion after the exposure of forskolin (11.8 ± 2.4 nmol·min−1·cm−2 vs. 9.1 ± 1.5 nmol·min−1·cm−2, p = 0.195). *: denotes a significant difference (p < 0.05).