Table 4.
Randomized, controlled trials of PDE5-I.
| Study population | Efficacy for treatment of PE | Side effects |
|---|---|---|
| 42 randomized | Fold increase in IELT (vardenafil): 7.3 | Headache |
| 40 completed | Fold increase in IELT (placebo): 1.3 | Dyspepsia |
| Drug: vardenafil | Statistically significant increase in: | Flushing |
| • control | ||
| • satisfication | ||
| • distress | ||
| 157 randomized | Fold increase in IELT (sildenafil): 2.6 | Headache |
| 144 completed | Fold increase in IELT (placebo): 1.6 | Flushing |
| Drug: sildenafil | Moderate increase in patient satisfaction | Dyspepsia |
| Abnormal vision | ||
| Rhinitis |
IELT, intravaginal ejaculation latency time; PE, premature ejaculation.