. 2011 Oct;3(5):211–222. doi: 10.1177/1756287211424172

Table 5.

Efficacy and side effects of drugs used in the management of PE.

Drug	Dose	Usage	Side effects	Relative increase in IELT
Clomipramine	12.5–50 mg	PRN Daily dose	Fatigue	4
			Nausea
			Dizziness
			Dry mouth
			Hypotension
Unlicensed SSRI Escitalopram Fluoxetine Fluvoxamine Paroxetine Sertraline	20–40 mg 20–40 mg 25–50 mg 10–40 mg 50–200 mg	Daily dose	Fatigue
			Nausea	2
			Diarrhoea	5
			Yawning	1.5
			Diaphoresis	8
			ED	5
			Decreased libido

Dapoxetine (licensed SSRI)	30–60 mg	PRN	Nausea	2.5–3.0
Dapoxetine (licensed SSRI)			Diarrhoea
			Headache
			Dizziness
Desensitizing agents EMLA SS Cream TEMPE (PSD502)	Smear	PRN	Messy Numbing of the vagina Skin irritation ED	4–8
Desensitizing agents EMLA SS Cream TEMPE (PSD502)	Smear Spray		Messy Numbing of the vagina Skin irritation ED
PDE5-I Vardenafil	10 mg		PRN	Headache	3
				Flushing
				Nausea
Tramadol	50 mg	PRN	Dizziness	3.6–7.0
			Drowsiness
			Nausea
			Constipation

IELT, intravaginal ejaculation latency time; PE, premature ejaculation; ED, erectile dysfunction; SSRI, selective serotonin reuptake inhibitor; PRN, pro re nata.