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. Author manuscript; available in PMC: 2011 Oct 24.
Published in final edited form as: Biochemistry. 2006 Jul 25;45(29):8978–8987. doi: 10.1021/bi060440o

Figure 12. Hypothetical scheme for spontaneous de-sulfuration of the GRx1-sporidesmin adduct.

Figure 12

This scheme depicts one plausible mechanism by which the adduct of GRx1 and sporidesmin might spontaneously lose 2 sulfur atom equivalents yet remain intact as a disulfide-bonded bimolecular complex. (As indicated in the text, there are other conceivable ways to lose 64 Da of mass, e.g., loss of four oxygens, or 2 oxygens and 1 sulfur).