Table 1. ABC transporter promoters possess binding sites for EMT transcription factors.
|
Binding sites for EMT-inducing transcription factors |
|||||
|---|---|---|---|---|---|
| ABC genes | E-Box | Twist | FKHD | E12 | E47 |
| ABCA2 | 15 | 9 | 2 | 2 | 3 |
| ABCA3 | 16 | 3 | 6 | 2 | 2 |
| ABCB1 | 3 | 1 | 22 | 0 | 1 |
| ABCB4 | 6 | 6 | 7 | 2 | 3 |
| ABCB5 | 1 | 4 | 13 | 0 | 3 |
| ABCB11 | 1 | 4 | 12 | 0 | 2 |
| ABCC1 | 2 | 11 | 12 | 1 | 6 |
| ABCC2 | 1 | 3 | 13 | 0 | 1 |
| ABCC3 | 4 | 4 | 2 | 1 | 2 |
| ABCC4 | 11 | 3 | 3 | 0 | 1 |
| ABCC5 | 6 | 2 | 9 | 0 | 2 |
| ABCC6 | 4 | 2 | 11 | 1 | 0 |
| ABCC10 | 3 | 2 | 14 | 0 | 1 |
| ABCC11 | 0 | 8 | 23 | 1 | 2 |
| ABCC12 | 3 | 5 | 9 | 2 | 1 |
| ABCG2 | 6 | 1 | 12 | 1 | 1 |
Bioinformatic analysis (using the MatInspector software) of promoters of ABC transporters for the presence of binding sites for EMT-inducing transcription factors.