Table 2.
Top associated SNPs (p < 00.001) in the overall sample on chromosome 12p11
| Overall Data Set (N = 897) | Dominican Subset (N = 368) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | MB | Gene | Function | Minor Allele | MAF | Beta | SE | P* | MAF | Beta | SE | P† |
| rs10743465 | 23.315 | SOX5 | flanking | A | 0.202 | -0.066 | 0.015 | 1.27E-05 | 0.23 | -0.043 | 0.022 | 5.11E-02 |
| rs4321001 | 23.323 | SOX5 | flanking | A | 0.195 | -0.064 | 0.015 | 1.69E-05 | 0.22 | -0.036 | 0.021 | 9.76E-02 |
| rs16919217 | 32.110 | BICD1 | flanking | C | 0.079 | -0.085 | 0.020 | 2.31E-05 | 0.11 | -0.082 | 0.027 | 2.68E-03 |
| rs6582621 | 44.878 | SLC38A1 | intron | A | 0.268 | -0.054 | 0.013 | 3.91E-05 | 0.29 | -0.062 | 0.020 | 2.17E-03 |
| rs16919218 | 32.110 | BICD1 | flanking | T | 0.082 | -0.081 | 0.020 | 4.96E-05 | 0.11 | -0.082 | 0.027 | 2.99E-03 |
| rs7958592 | 23.399 | SOX5 | flanking | C | 0.340 | -0.048 | 0.012 | 6.33E-05 | 0.38 | -0.047 | 0.018 | 7.80E-03 |
| rs11183394 | 44.882 | SLC38A1 | intron | A | 0.239 | -0.054 | 0.013 | 6.50E-05 | 0.25 | -0.060 | 0.021 | 4.30E-03 |
| rs10047623 | 23.368 | SOX5 | flanking | G | 0.092 | -0.078 | 0.020 | 8.28E-05 | 0.12 | -0.066 | 0.027 | 1.70E-02 |
| rs4129991 | 23.340 | SOX5 | flanking | G | 0.202 | -0.059 | 0.015 | 8.28E-05 | 0.23 | -0.038 | 0.021 | 7.54E-02 |
| rs7307902 | 46.209 | intergenic | G | 0.213 | 0.050 | 0.014 | 2.98E-04 | 0.19 | 0.022 | 0.022 | 3.14E-01 | |
| rs1967110 | 48.681 | RACGAP1 | intron | G | 0.086 | -0.075 | 0.021 | 2.99E-04 | 0.09 | -0.063 | 0.031 | 3.86E-02 |
| rs7133522 | 44.888 | SLC38A1 | intron | T | 0.292 | -0.046 | 0.013 | 3.48E-04 | 0.31 | -0.055 | 0.019 | 4.53E-03 |
| rs12310555 | 29.278 | FAR2 | intron | A | 0.189 | -0.053 | 0.015 | 3.97E-04 | 0.21 | -0.083 | 0.023 | 2.88E-04 |
| rs7955257 | 23.376 | SOX5 | flanking | T | 0.260 | -0.044 | 0.013 | 4.64E-04 | 0.28 | -0.038 | 0.019 | 4.78E-02 |
| rs17128396 | 39.198 | intergenic | A | 0.063 | -0.082 | 0.024 | 5.80E-04 | 0.07 | -0.055 | 0.034 | 1.03E-01 | |
| rs7956629 | 44.877 | SLC38A1 | intron | A | 0.120 | -0.061 | 0.018 | 7.18E-04 | 0.14 | -0.065 | 0.026 | 1.27E-02 |
| rs7310702 | 44.535 | ARID2 | intron | G | 0.168 | -0.055 | 0.016 | 7.78E-04 | 0.19 | -0.044 | 0.023 | 5.90E-02 |
| rs12227330 | 49.969 | BIN2 | intron | A | 0.121 | -0.063 | 0.019 | 7.95E-04 | 0.12 | -0.062 | 0.028 | 2.98E-02 |
| rs10875764 | 46.869 | C12orf68 | flanking | C | 0.482 | 0.039 | 0.012 | 8.34E-04 | 0.46 | 0.035 | 0.019 | 5.94E-02 |
| rs309045 | 28.841 | intergenic | A | 0.413 | 0.039 | 0.012 | 9.07E-04 | 0.36 | 0.017 | 0.018 | 3.39E-01 | |
*adjused for PCA1, PCA2, age, sex, hypertension, diabetes, BMI, WC, and years between LVM and risk factor measurements
† adjusted for PCA1, age, sex, hypertension, diabetes, BMI, WC, and years between LVM and risk factor measurements.