Table 3.
Overall (N = 897) | High WC (N = 495) | Low WC (N = 402) | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | MB | Gene | Function | Minor Allele | Beta | SE | P* | Beta | SE | P* | Beta | SE | P* | Difference in Betas | P† |
rs1157480 | 30.264 | TMTC1 | flanking | A | 0.004 | 0.014 | 7.88E-01 | 0.053 | 0.019 | 6.30E-03 | -0.056 | 0.021 | 8.20E-03 | 0.109 | 1.37E-04 |
rs1124636 | 26.424 | ITPR2 | intron | T | -0.016 | 0.014 | 2.54E-01 | 0.032 | 0.019 | 9.31E-02 | -0.072 | 0.020 | 2.85E-04 | 0.104 | 1.45E-04 |
rs9669515 | 30.261 | TMTC1 | flanking | T | 0.002 | 0.014 | 8.74E-01 | 0.049 | 0.019 | 1.04E-02 | -0.055 | 0.021 | 8.68E-03 | 0.104 | 2.31E-04 |
rs7970841 | 30.274 | TMTC1 | flanking | T | -0.007 | 0.015 | 6.31E-01 | 0.042 | 0.020 | 3.04E-02 | -0.064 | 0.021 | 3.03E-03 | 0.106 | 2.46E-04 |
rs7963790 | 38.515 | SLC2A13 | intron | C | 0.022 | 0.013 | 1.03E-01 | 0.064 | 0.017 | 2.40E-04 | -0.030 | 0.019 | 1.20E-01 | 0.095 | 2.87E-04 |
rs10877703 | 38.561 | SLC2A13 | intron | A | 0.012 | 0.013 | 3.37E-01 | 0.052 | 0.017 | 2.47E-03 | -0.041 | 0.019 | 3.22E-02 | 0.093 | 2.87E-04 |
rs1679695 | 28.845 | CCDC91 | flanking | T | -0.044 | 0.022 | 5.20E-02 | -0.106 | 0.028 | 2.12E-04 | 0.050 | 0.035 | 1.55E-01 | 0.156 | 5.56E-04 |
rs326644 | 32.293 | BICD1 | intron | C | -0.009 | 0.012 | 4.41E-01 | 0.024 | 0.016 | 1.34E-01 | -0.059 | 0.018 | 1.23E-03 | 0.083 | 5.73E-04 |
rs261889 | 32.371 | BICD1 | intron | T | 0.014 | 0.014 | 3.40E-01 | -0.030 | 0.019 | 1.11E-01 | 0.066 | 0.021 | 1.65E-03 | 0.096 | 6.18E-04 |
rs326641 | 32.291 | BICD1 | intron | T | 0.015 | 0.014 | 2.75E-01 | 0.059 | 0.018 | 1.23E-03 | -0.032 | 0.020 | 1.06E-01 | 0.091 | 6.82E-04 |
rs2650128 | 32.352 | BICD1 | intron | G | 0.014 | 0.015 | 3.32E-01 | -0.026 | 0.019 | 1.77E-01 | 0.074 | 0.023 | 1.10E-03 | 0.100 | 7.10E-04 |
rs4356315 | 31.105 | DDX11 | flanking | G | 0.014 | 0.012 | 2.38E-01 | 0.050 | 0.015 | 1.18E-03 | -0.028 | 0.017 | 1.07E-01 | 0.078 | 7.21E-04 |
rs11610493 | 40.345 | PDZRN4 | flanking | G | 0.014 | 0.013 | 2.57E-01 | -0.023 | 0.017 | 1.70E-01 | 0.061 | 0.018 | 1.05E-03 | 0.084 | 7.82E-04 |
*adjusted for PCA1, PCA2, age, sex, hypertension, diabetes, BMI, WC, and years between LVM and risk factor measurements
† p-value calculated using a normal approximation to test for differences between the beta coefficients of high and low WC.