Table 1.

Parameters and data in simulations

Parameter/Data	Symbol	Distribution	Value(mode)	cv	Unit
RK2 abundance	D0	lognormal	4.5	0.5	nM
KorA abundance	Atot	lognormal	1600 [18]	0. 5	nM
KorB abundance	Btot	lognormal	400 [28]	0. 5	nM
KorB abundance (mutant)	BMtot	lognormal	920	0. 5	nM
Scaling parameter for KorA synthesis	πX	uniform	[0,1]	-	-
Scaling parameter for KorB synthesis	πY	uniform	[0,1]	-	-
KorA synthesis	kA	-	-	-	s-1
KorB synthesis	kB	-	-	-	s-1
KorA affinity to DNA	k1	lognormal	12.9 [18]	0. 5	nM
KorB affinity to DNA	k2	lognormal	9.3 [22]	0. 5	nM
KorA affinity to KorB-DNA	k3	lognormal	3.1	0. 5	nM
KorB affinity to KorA-DNA	k4	lognormal	3.1 [22]	0. 5	nM
KorA monomerization	σA	-	-	-	s-1
KorB monomerization	σB	-	-	-	s-1
KorA dimerization	λA	lognormal	0.001	0.05	nM-1s-1
KorB dimerization	λB	lognormal	0.001	0.05	nM-1s-1
Protein degradation	γP	lognormal	0.0003875	0.05	s-1

cv - coefficient of variation; RK2 abundance (D₀) and protein degradation (γ_P) are calculated for bacteria with the population doubling time of 43 minutes; KorB abundance for plasmid mutant (BM_tot) is unpublished data from C. Thomas et al.; affinity of KorA to the KorB-DNA complex (k₃) were assumed to be three fold higher as it is in the case of affinity of KorB to the KorA-DNA complex (k₄); dimerization rates were defined by diffusion properties.