Table 1.
Characteristics of ART-naïve and experienced HIV-patients in Hasan Sadikin Hospital, September 2007 - August 2009 (n = 869)
| Characteristics | ART naïve | ART experienced | p value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Total n = 611 |
No anemia n = 304 |
Mild n = 186 |
Moderate-severe n = 114 |
Total n = 258 |
No anemia n = 216 |
Mild n = 37 |
Moderate-severe n = 5 |
||
| Male sex, % | 68.2 | 67.1 | 68.8 | 69.3 | 81.6 | 83.6 | 73.0 | 60.0 | < 0.001 |
| Median age, yrs (IQR) | 28 (26-31) | 28 (25-30) | 29 (26-32) | 29 (26-34) | 29 (26-32) | 29 (26-32) | 30 (26-34) | 31 (29-31) | 0.45 |
| Median BMI, kg/m2 (IQR) |
19.5 (17.3-22.0) |
19.8 (17.8-22.6) |
19.1 (16.9-21.6) |
19.6 (16.8-21.8) |
20.3 (18.6-22.5) |
20.4 (18.5-22.5) |
20.2 (18.5-22.3) |
17.8 (15.7-22.1) |
0.63 |
| History of IDU, % | 63.1 | 64.9 | 61.8 | 61.0 | 84.4 | 86.5 | 78.4 | 40.0 | < 0.001 |
| Anti HCV (+), % | 58.5 | 59.6 | 61.3 | 50.0 | 80.0 | 84.0 | 64.7 | 25.0 | < 0.001 |
| Median CD4, cells/mm3 (IQR) |
76 (20-305) |
232 (66-406) |
45 (15-144) |
17 (6-45) |
272 (201-395) |
280 (220-425) |
195 (128-314) |
190 (72-375) |
< 0.001 |
| TB treatment, % | 21.3 | 6.3 | 27.4 | 50.9 | 3.9 | 2.8 | 5.4 | 40.0 | < 0.001 |
| Oral Candidiasis, % | 27.8 | 21.8 | 35.4 | 31.4 | 3.3 | 2.0 | 5.7 | 40.0 | < 0.001 |
| Median MCV (IQR) (fl) | 84.3 (80.3-87.5) |
85.8 (82.8-88.6) |
82.8 (77.6-86.4) |
81.3 (76.0-84.7) |
108.5 (103.0-114.0) |
109.0 (104.0-114.0) |
108.0 (99.8-114.0) |
88.4 (81.0-100.1) |
< 0.001 |
| Median MCH (IQR) (pg) | 28.9 (27.3-30.2) |
29.5 (28.2-30.5) |
28.4 (25.9-29.8) |
27.8 (25.7-29.2) |
38.4 (36.0-40.6) |
38.4 36.3-40.7) |
39.0 (34.2-40.5) |
29.2 (27.7-33.8) |
0.58 |
| Reticulocyte index (%) | 0.8 (0.6-1.5) | 1.0 (0.6-1.8) | 0.8 (0.6-1.0) | 1.0 (0.5-2.7) | 0.8 (0.6-1.0) | 0.9 (0.7-1.4) | 0.6 (0.5-1.0) | 1.0 (1.0-1.0) | 0.02 |
* p value for difference between ART-naïve and experienced group
Mild anemia: Hb 10.5 - 12.99 g/dL for men; and 10.5 - 11.99 g/dL for women, moderate-severe anemia: Hb < 10.5 g/dL.
TB treatment: receive TB treatment in presentation or within 3 months of presentation
Anemia status missing in 7 patients, gender in 3 patients, age in 1 patients, BMI in 151 patients, IDU status in 46 patients, anti HCV in 117 patients, CD4 in 13 patients, oral candidiasis in 94 patients, reticulocyte index only available from 184 patients
BMI: body mass index; IDU: injecting drug user; HCV: Hepatitis C virus; TB: tuberculosis; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; IQR: interquartile range.