Table 2.
Multivariate analysis for factors related to six-month mortality among ART-naïve patients (n = 611) in Hasan Sadikin Hospital, September 2007 - August 2009
| Base Analysis | Sensitivity Analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| n | Mortality | Univariate | Multivariate | Multivariate | ||||
| HR (95% CI) | p value | HR adjusted (95% CI) | p value | HR adjusted (95% CI) | p value | |||
| Gender | ||||||||
| Female | 194 | 5 | 1 | 1 | 1 | |||
| Male | 416 | 29 | 2.8 (1.1-7.4) | 0.03 | 1.5 (0.5-4.3) | 0.46 | 1.8 (0.5-6.2) | 0.32 |
| Age (years old) | ||||||||
| < 29 | 317 | 11 | 1 | 1 | 1 | |||
| ≥29 | 294 | 23 | 2.3 (1.1-4.9) | 0.02 | 1.6 (0.7-3.5) | 0.24 | 1.4 (0.5-6.2) | 0.49 |
| CD4 (cells/mL) | ||||||||
| > 50 | 353 | 4 | 1 | 1 | 1 | |||
| ≤ 50 | 248 | 29 | 11.6 (4.0-33.3) | < 0.001 | 5.7 (1.8-17.8) | 0.003 | 6. 1 (1.6-23.1) | 0.008 |
| BMI (kg/m2) | ||||||||
| ≥18.5 | 183 | 9 | 1 | |||||
| < 18.5 | 299 | 13 | 1.1 (0.5-2.7) | 0.77 | ||||
| Anemia, (%) | ||||||||
| No anemia | 304 | 4 | 1 | 1 | 1 | |||
| Mild | 186 | 10 | 3.8 (1.2-12.6) | 0.03 | 2.2 (0.6-7.6) | 0.21 | 2.6 (0.6-11.1) | 0.19 |
| Moderate and severe | 114 | 20 | 16.0 (5.3-47.9) | < 0.001 | 6.5 (2.0-21.2) | 0.002 | 10.9 (2.7-44.3) | 0.001 |
| History of IDU, (%) | ||||||||
| No | 209 | 11 | 1 | |||||
| Yes | 357 | 21 | 1.1 (0.5-2.4) | 0.76 | ||||
| ART, (%) | ||||||||
| No | 324 | 14 | 1 | |||||
| Yes | 287 | 20 | 1.7 (0.8-3.3) | 0.12 | ||||
*Data were missing for gender (n = 1), CD4 (n = 10), BMI in 482 patients (n = 129), anemia status (n = 7), history of IDU (n = 45).
Sensitivity analysis: subjects with TB treatment within 3 months presentation excluded from analysis
Mild anemia: Hb 10.5 - 12.99 g/dL for men; and 10.5 - 11.99 g/dL for women, moderate-severe anemia: Hb < 10.5 g/dL.
ART: receive ART within 6 of presentation.
BMI, body mass index; IDU: injecting drug user; ART, anti retroviral; HR, hazard ratio;