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. 2011 Aug 3;11:333. doi: 10.1186/1471-2407-11-333

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Copyright ©2011 Krust et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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HB-19 and related Nucant pseudopeptides inhibit the production of TNF-α and IL-6 by peripheral blood lymphocytes. The production of pro-inflammatory cytokines in PBMC cultures stimulated with HKSA was carried out in triplicate in the absence (Control) or presence of 10 μM of each of HB-19, N3, N6, N7, N6L, or 1 μg/ml of dexamethasone (Dex.)(Methods). The level of TNF-α (section A) and IL-6 (section B) was monitored in culture supernatants by ELISA. The data presents the mean ± SD of triplicate samples. The degree of inhibition is indicated at the top of each histogram. Statistical significance: **p < 0.01, ***p < 0.001.