Table 3.
Clinical, functional and neuropsychological test performance of subjects with pre-MCI and aMCI
| Pre-MCI (n = ll) | e-aMCI (n = 15) | 1-aMCI (n = 15) | p value |
|||
|---|---|---|---|---|---|---|
| ANOVA | pre-vs. e-aMCI | e-vs. 1-aMCI | ||||
| Cognitive and functional testing | ||||||
| CMMSE (mean ± SD), n/28 | 26.09 ± 1.38 | 23.33 ± 3.56 | 20.60 ± 4.12 | 0.001 | 0.140 | 0.10 |
| CSDD (mean ± SD) | 2.56 ± 3.91 | 3.07 ± 4.03 | 6.57 ± 4.96 | 0.05 | 1.00 | 0.11 |
| Total Lawton score (mean ± SD), n/23 | 20.50 ± 2.07 | 20.93 ± 2.02 | 16.93 ± 4.97 | 0.007 | 1.00 | 0.009 |
| MTA score (mean ± SD) | 0.67 ± 1.03 | 1.00 ± 0.00 | 2.11 ± 1.17 | 0.06 | 1.00 | 0.62 |
| Presence of lacunar infarcts, n (%) | 7 (63.6) | 8 (53.3) | 5 (35.7) | 0.36 | ||
| WML global score (mean ± SD) | 6.55 ± 3.08 | 3.93 ± 2.58 | 6.07 ± 1.15 | 0.057 | 0.09 | 0.17 |
| Neuropsychological testing (z-scores) | ||||||
| Immediate memory | 0.59 (0.74) | −1.26 (0.98) | −0.94 (1.16) | <0.001 | <0.001 | 1.00 |
| Recognition memory | 0.68 (0.40) | −1.27 (1.47) | −1.39 (1.32) | <0.001 | <0.001 | 1.00 |
| Delayed memory | 0.60 (0.59) | −1.29 (0.32) | −1.49 (0.63) | <0.001 | <0.001 | 0.90 |
| Animal category | −0.16 (0.73) | −0.55 (1.09) | −0.85 (0.98) | 0.21 | 0.93 | 1.00 |
| Boston Naming Test | 0.42 (0.55) | −0.67 (1.37) | −0.64 (1.42) | 0.06 | 0.10 | 1.00 |
| Block design | 0.20 (1.02) | −0.70 (1.20) | −0.56 (0.59) | 0.06 | 0.08 | 1.00 |
| Object assembly | −0.15 (1.17) | −0.99 (1.26) | −0.78 (1.16) | 0.22 | 0.27 | 1.00 |