1. |
Cerebral malaria. GCS < 11. |
2. |
Shock. Systolic blood pressure <80 mmHg, with cool extremities |
3. |
Severe anaemia. Haematocrit <20%, with parasite count > 100,000/μl |
4. |
Liver disease. Total bilirubin > 42 μmol/L with parasite count > 100,000/μl |
5. |
Hyperparasitaemia. Peripheral parasite count >10% |
6. |
Acidosis. Venous bicarbonate <15 mmol/L |
On admission, or developing within the first 72 hours: |
7. |
Hypoglycaemia. Blood glucose <2.2 mmol/L |
8. |
Convulsions |
9. |
Pulmonary oedema |
10. |
Renal failure. Plasma creatinine > 265 μmol/L |