Table 4.
Baseline patient characteristics classified by admission creatinine clearance
| Variable | All patients n = 163 | CrCl > 60 ml/min n = 79 | CrCl < 60 ml/min n = 84 | P |
|---|---|---|---|---|
| Age (years) | 35 (23 - 45) | 30 (23 - 40) | 37 (23 - 50) | 0.02 |
| Male sex | 136/163 (80%) | 66/79 (84%) | 64/84 (76%) | 0.33^ |
| Parasite count % (peripheral) | 2.7 (0.9 - 9.5) | 1.9 (0.7 -4.9) | 3.6 (1.1 - 11.3) | 0.003 |
| Glasgow Coma Score | 8 (7 - 9) | 8 (6 - 10) | 9 (5 - 11) | 0.8 |
| Mean arterial pressure (mmHg) | 80 (73 - 90) | 81 (73 - 93) | 80 (70 - 87) | 0.2 |
| Heart rate (beats per minute) | 113 (102 - 131) | 112 (94 - 131) | 114 (103 - 134) | 0.54 |
| Respiratory rate (breaths per minute) | 30 (26 - 36) | 30 (25 - 36) | 30 (26 - 36) | 0.53 |
| Oxygen saturation (%) | 96 (94- 97) | 96 (94 - 98) | 96 (93 - 97) | 0.61 |
| Glucose (mmol/L) | 6.8 (5.3 - 10.1) | 7.2 (5.7 - 7.2) | 6.3 (4.9 - 9) | 0.09 |
| Sodium (mmol/L) | 133 (128 - 137) | 132 (128 - 137) | 133(129 - 139) | 0.28 |
| Potassium (mmol/L) | 4.3 (3.8 - 4.8) | 4.2 (3.7 - 4.6) | 4.5 (3.8 - 4.9) | 0.03 |
| Bicarbonate (mmol/L) | 16.9 (15 - 17.5) | 19.3 (16 - 21.3) | 14 (12 - 17.1) | 0.0001 |
| Base excess | -8 (-12 - -3) | -5 (-8 - -2) | -11 (-16 - -7) | 0.0001 |
| Lactate | 4.7 (3.3-7.2) | 4.3 (3.1 -5.5) | 5.6 (3.7 -10.1) | 0.002 |
| Blood urea nitrogen (mmol/L) | 14.7 (9 -26) | 9.2 (6.4 - 12.1) | 24.9 (18 - 34.3) | 0.0001 |
| Plasma creatinine (μmol/L) | 122 (79.6 - 202) | 79.2 (61.6 - 97.2) | 202 (142 - 316) | 0.0001 |
| Haematocrit (%) | 29 (23 - 35) | 32 (26 - 36) | 29 (23 - 35) | 0.06 |
| Urinary sodium (mmol/L) | 44 (30 - 66) | 48 (30 - 79) | 40 (30 - 63) | 0.35 |
| FeNa | 0.71 (0.28 - 1.37) | 0.39 (0.2 - 0.84) | 1.05 (0.52 - 2.11) | 0.0001 |
| RFI | 0.95 (0.4 - 1.8) | 0.5 (0.2 - 1.1) | 1.3 (0.7 - 2.8) | 0.0001 |
| UOsm (mosm/L) | 498 (391 - 674) | 614 (503 - 725) | 412 (357 - 518) | 0.0001 |
| FeUN | 46 (29 - 65) | 51 (38 - 66) | 37 (24 - 64.5) | 0.001 |
| UPCR | 53 (29.9 - 85.1) | 80.5(60.3 - 115.8) | 32.6 (19 - 46.9) | 0.0001 |
| Urea:creatine ratio | 29.4 (21.8 - 37.8) | 28.7 (20 - 38.4) | 29.4 (22.4 - 37) | 0.86 |
| Plasma bilirubin (total) (μmol/L) | 72 (35.9 - 160) | 61.1 (29.9 - 111.3) | 94.7(43.3 - 204.9) | 0.01 |
| Plasma bilirubin (direct) (μmol/L) | 28.6 (12 - 77) | 18.6 (10.4 - 42.8) | 44 (18.8 - 113.3) | 0.0001 |
| NGAL | 322 (226 - 586) | 232 (171 - 333) | 468 (304 - 733) | 0.0001 |
All numbers, except male sex, are medians (interquartile range)
All P values comparing the populations with CrCl > 60 ml/min and CrCl < 60 ml/min are determined using Kruskal-Wallis, except ^ Fisher's exact.
CrCl: creatinine clearance, FeNa: Fractional Excretion of sodium, RFI: Renal Failure Index, UOsm: Urinary osmolality. FeUN: Fractional excretion of urea nitrogen, UPCR: urine:plasma creatinine ratio, UCR: plasma urea:creatinine ratio (n.b. non SI units), NGAL: neutrophil gelatinase-associated lipocalcin.