. Author manuscript; available in PMC: 2011 Oct 24.

Published in final edited form as: J Nat Prod. 2011 May 12;74(6):1437–1443. doi: 10.1021/np200181d

Table 2.

Potencies (EC₅₀) and Efficiencies (Maximum Stimulation of the GABA-Induced Chloride Current) of Compounds 1–6 for GABA_A Receptors of the Subunit Composition α₁β₂γ_2S

compd	EC₅₀ [μM] ± SE	maximum stimulation of I_GABA (EC_5–10) ± SE [%]	Hill coefficient^a (n_H) ± SE	no. of experiments (n)
1	171.5 ± 34.6	1200 ± 163	1.8 ± 0.2	6
2	65.3 ± 21.6	588 ± 126	1.6 ± 0.3	5
3	64.8 ± 19.8	669 ± 112	1.7 ± 0.3	6
4	135.1 ± 34.4	886 ± 105	1.6 ± 0.2	5
5	109.4 ± 46.6	164 ± 42.9	2.1 ± 0.8	6
6	34.0 ± 6.7	241 ± 23.1	1.6 ± 0.3	5

Indicates the slope of the concentration–response curve at the EC₅₀. Hill coefficients > 1 indicate positive cooperativity during receptor binding.⁶²