TABLE 5.

SIGNIFICANT VDR SNP ASSOCIATIONS WITH ASTHMA CHARACTERISTICS

dbSNP rs#	Characteristic	Genotypic Model		Dominant Model‡
		Adjusted Parameter Estimate* (95%Cl)	Adjusted* P Value	Adjusted Parameter Estimate* (95%Cl)	Adjusted* P Value
rs7975232	FEF25–75 (% predicted) change with bronchodilator	11.2 (−0.4 to 22.7)	0.06	7.95 (0.63 to 15.27)	0.034
rs2239185	FEV1/FVC (%) pre-bronchodilator	−3.0 (−7.3 to 1.3)	0.16	−3.3 (−6.2 to −0.4)	0.025
rs2107301	† Serum Eosinophil Level	0.20 (0.06 to 0.33)	0.004	0.09 (0.01 to 0.18)	0.028
rs1540339	† Serum Eosinophil Level	0.18 (0.05 to 0.32)	0.008	0.09 (0.01 to 0.18)	0.029
rs3782905	FEV1/FVC (%) pre-bronchodilator	−3.9 (−8.3 to 0.5)	0.08	−3.2 (−6.0 to −0.4)	0.025
rs3782905	FEV1/FVC (%) change with bronchodilator	4.7 (0.9 to 8.4)	0.016	2.7 (0.4 to 5.2)	0.022
rs3782905	FEF25–75 (% predicted) pre-bronchodilator	−8.8 (−16.6 to 1.0)	0.08	−7.8 (−14.1 to −1.6)	0.014
rs2228570	≥1 Positive Skin Prick Test		N/A^	3.8 (1.57 to 9.18)	0.003
rs2228570	† Serum IgE Level (IU/mL)	0.34 (0.12 to 0.56)	0.002	0.24 (0.11 to 0.37)	<0.001
rs2228570	† ITG Functional Limitations Score	−0.04 (−0.1 to −0.002)	0.043	−0.03 (−0.52 to 0.0)	0.052
rs2228570	FEV1/FVC (%) pre-bronchodilator	−5.9 (−10.9 to −0.9)	0.022	−3.7 (−6.8 to −0.7)	0.017
rs2228570	FEV1/FVC (%) change with bronchodilator	5.1 (0.8 to 9.5)	0.022	2.4 (−0.3 to 5.1)	0.08
rs2228570	FEF25–75 (% predicted) pre-bronchodilator	−11.5 (−23.0 to −0.1)	0.049	−7.0 (−13.9 to 0.0)	0.050

^‡Dominant model: Presence of at least 1 minor allele for the given SNP

^*Adjusted for age, gender, and BMI percentile

Parameter estimate for linear regression analyses expressed as B

Parameter estimate for logistic regression analyses expressed as Exp(B)

^{^}Only dominant model analysis was performed for outcomes with nominal values

^†Outcome was transformed to a log₁₀ scale

Adjusted P Values ≤ 0.05 are indicated in bold.