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. Author manuscript; available in PMC: 2012 Feb 25.
Published in final edited form as: J Mol Biol. 2010 Dec 30;406(3):491–502. doi: 10.1016/j.jmb.2010.12.028

Figure 8.

Figure 8

Tramprosate does not inhibit amyloid formation by proIAPP1–48 or by the proIAPP1–48/heparan sulfate mixture. Time course of amyloid fibril formation monitored by fluorescence detected thioflavin-T binding: proIAPP1–48 alone (black); a 40:1 molar ratio mixture of tramprosate and proIAPP1–48 (red); proIAPP1–48/heparan sulfate (green); a 40:1 molar ratio mixture of tramprosate and proIAPP1–48/heparan sulfate (blue). The pH of the solutions was 7.4. The solutions contained 2% HFIP by volume, 20mM Tris-HCl, 25 µM thioflavin-T, 32 µM peptide and were continually stirred at 25°C.