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Effect of receptor inhibitor of GIP, GLP-1, or GLP-2 on l-Glu/IMP-induced HCO3− secretion in rat duodenum. Vehicle (Veh), Pro3GIP (30 nmol/kg) (A), Ex-3(9-39) (30 nmol/kg) (B), or GLP-2(3-33) (3 nmol/kg) (C) was bolus intravenously injected at t = 10 min followed by luminal coperfusion of l-Glu (10 mM) and IMP (0.1 mM). Each data point represents mean ± S.E.M. (n = 6 rats). *, p < 0.05 versus pH 7.0 Krebs group. †, p < 0.05 versus intravenous vehicle + l-Glu + IMP group.
