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. 2011 Nov;339(2):464–473. doi: 10.1124/jpet.111.184788

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Fig. 7. — Effect of intravenous VIP(6-28) or l-NAME coperfusion on l-Glu/IMP-induced HCO₃⁻ secretion in rat duodenum. A, VIP(6-28) (30 nmol/kg) was bolus intravenously injected at t = 10 min followed by luminal perfusion of l-Glu (10 mM) and IMP (0.1 mM). Each data point represents mean ± S.E.M. (n = 6 rats). *, p < 0.05 versus pH 7.0 Krebs group. †, p < 0.05 versus vehicle (Veh) intravenous+ l-Glu + IMP group. B, l-NAME (0.1 mM) with or without l-Arg (10 mM) was luminally coperfused with l-Glu and IMP. Each data point represents mean ± S.E.M. (n = 6 rats). *, p < 0.05 versus pH 7.0 Krebs group. †, p < 0.05 versus l-Glu + IMP group. ‡, p < 0.05 versus l-Glu + IMP + l-NAME group.