TABLE 2.

Correlation coefficients (r) between P450 amount and drug-metabolizing enzyme activities in cynomolgus monkey livers

Metabolic activities were measured as described under Materials and Methods. Values are mean ± S.D. for 27 cynomolgus monkeys.

	Activity	Total P450	2A	2B6	2C9/19	2C76	2D	2E1	3A4	3A5	3A
	nmol/min/mg protein
Bufuralol 1′-hydroxylation	0.79 ± 0.26	0.29	0.25	−0.12	0.15	0.43*	0.65***	−0.09	−0.37	0.42*	−0.10
Coumarin 7-hydroxylation	0.097 ± 0.061	0.15	0.14	−0.11	−0.15	0.12	0.44*	0.08	−0.26	−0.02	−0.22
Dextromethorphan N-deethylation	0.12 ± 0.047	0.11	0.37	−0.18	−0.31	0.01	0.08	0.13	0.46**	0.02	0.20
Dextromethorphan O-deethylation	0.63 ± 0.52	0.18	0.31	0.08	−0.01	0.33	0.66***	0.10	−0.51	0.16	−0.35
Diclofenac 4-hydroxylation	0.13 ± 0.033	0.30	0.02	−0.18	0.38*	0.16	0.12	0.07	0.22	0.31	0.34
7-Ethoxyresorufin O-deethylation	0.092 ± 0.056	0.06	0.47*	−0.01	−0.22	0.39*	0.04	−0.22	−0.25	−0.21	−0.31
Midazolam 1′-hydroxylation	1.78 ± 0.56	0.44*	0.08	0.43*	0.32	0.28	0.11	−0.16	0.51**	0.22	0.53**
Midazolam 4-hydroxylation	1.33 ± 0.41	0.40*	0.12	0.44*	0.45*	0.33	−0.05	−0.25	0.69***	0.07	0.61***
Pentoxyresorufin O-deethylation	0.0031 ± 0.00092	0.43*	0.32	0.05	0.11	0.39*	−0.15	−0.11	0.32	−0.03	0.25
Progesterone 6β-hydroxylation	3.01 ± 0.94	0.32	0.29	0.16	0.11	0.16	−0.16	0.02	0.51**	0.04	0.44*
Testosterone 2α-hydroxylation	0.16 ± 0.027	0.01	−0.02	0.08	0.02	−0.14	0.06	0.02	0.07	0.43*	0.27
Testosterone 6β-hydroxylation	4.87 ± 1.16	0.31	0.22	0.07	0.07	0.11	−0.08	−0.06	0.64***	0.06	0.56**
Testosterone 16α-hydroxylation	0.11 ± 0.074	0.12	−0.01	−0.39	−0.07	0.05	0.22	−0.07	−0.35	0.50**	−0.04
Testosterone 16β-hydroxylation	0.29 ± 0.070	0.29	0.13	0.42*	−0.02	0.23	0.23	−0.08	0.25	0	0.21

Statistical significance was determined based on the P value (probability that r is zero) of the linear regression: *, P < 0.05; **, P < 0.01; ***, P < 0.001.