Fig. 3.

Effects of presession treatments with rimcazole and its analogs on responding maintained by cocaine injection or food presentation. Each point represents the mean ± S.E.M. (n = 6). Rimcazole and its analogs were administered intraperitoneally at 5 min before sessions. A–C, effects of presession treatments with rimcazole and its analogs on cocaine self-administration. Ordinates, responses per second; abscissae, cocaine injection dose in milligrams per kilogram. A, effects of rimcazole (3.2, 10, and 32 mg/kg) on cocaine self-administration. B, effects of SH 3-24 (1.0, 3.2, and 10 mg/kg) on cocaine self-administration. C, effects of SH 3-28 (3.2, 10, and 32 mg/kg) on cocaine self-administration. D–F, effects of presession treatments with rimcazole and its analogs on responding maintained by cocaine injection (0.32 mg/kg per inj) or food presentation (fourth component, each). Ordinates, response rates as percentage of control response rates (sessions before drug tests), which averaged 0.40 (±0.13), and 0.91 (±0.10) response/s, respectively, for cocaine- and food-maintained responding; abscissae, milligrams per kilogram of test compounds administered intraperitoneally, log scale. ●, behavior maintained by cocaine (0.32 mg/kg per inj i.v.); ○, behavior maintained by food presentation.