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. 2011 Nov;339(2):662–677. doi: 10.1124/jpet.111.185025

Fig. 7.

Fig. 7.

Effects of presession treatments with methylphenidate (1.0 mg/kg) or nomifensine (0.32 mg/kg) combined with σR antagonists on cocaine self-administration. Ordinates, responses per second; abscissae, cocaine injection dose in milligrams per kilogram. Each point represents the mean ± S.E.M. (n = 6). Methylphenidate, BD1008, BD1047, and BD1063 were administered intraperitoneally at 5, 5, 15, and 5 min before sessions, respectively. A, effects of methylphenidate (1.0 mg/kg) with BD 1008 (1.0, 3.2, and 10 mg/kg) on cocaine self-administration. B, effects of methylphenidate with BD 1047 (1.0, 3.2, and 10 mg/kg) on cocaine self-administration. C, effects of methylphenidate with BD 1063 (1.0, 3.2, and 10 mg/kg) on cocaine self-administration. D, effects of nomifensine with BD 1008 (1.0, 3.2, and 10 mg/kg) on cocaine self-administration. E, effects of nomifensine with BD 1047 (1.0, 3.2, and 10 mg/kg) on cocaine self-administration. F, effects of nomifensine with BD 1063 (1.0, 3.2, and 10 mg/kg) on cocaine self-administration.