TABLE 2.
Results of statistical analysis of the effects of drug combinations on cocaine self-administration
| Treatment | Cocaine Dose | Pretreatment | Interaction | Post Hoc Test |
|
|---|---|---|---|---|---|
| At 0.1 mg/kg per Injection Cocaine | At 0.32 mg/kg per Injection Cocaine | ||||
| 0.1 mg/kg WIN 35,428 and BD 1008 | F4,40 = 6.38, p = 0.002 | F2,40 = 4.51, p = 0.040 | F8,40 = 3.57, p = 0.003 | N.S. | 10 mg/kg BD 1008, t = 5.84, p < 0.001 |
| 0.1 mg/kg WIN 35,428 and BD 1047 | F4,40 = 21.8, p < 0.001 | F2,40 = 1.22, p = 0.337 | F8,40 = 1.94, p = 0.081 | N.S. | N.S. |
| 0.1 mg/kg WIN 35,428 and BD 1063 | F4,40 = 4.15, p = 0.013 | F2,40 = 0.601, p = 0.567 | F8,40 = 0.63, p = 0.748 | N.S. | N.S. |
| 0.3 mg/kg WIN 35,428 and BD 1008 | F4,80 = 6.91, p = 0.001 | F4,80 = 5.68, p = 0.003 | F16,80 = 4.62, p < 0.001 | 1.0 mg/kg BD 1008, t = 3.00, p = 0.034 | 0.32–10 mg/kg BD 1008, t = 5.50, 5.59, 5.62, and 6.12, respectively, p <0.001 |
| 0.3 mg/kg WIN 35,428 and BD 1047 | F4,80 = 11.8, p < 0.001 | F4,80 = 1.65, p = 0.201 | F16,80 = 2.97, p < 0.001 | 0.32 mg/kg BD 1047, t = 4.03, p ≤ 0.002 | N.S. |
| 1.0 mg/kg BD 1047, t = 3.90, p ≤ 0.002 | |||||
| 0.3 mg/kg WIN 35,428 and BD 1063 | F4,80 = 14.2, p < 0.001 | F4,80 = 3.33, p = 0.030 | F16,80 = 4.54, p < 0.001 | 0.32 mg/kg BD 1063, t = 6.09, p ≤ 0.009 | N.S. |
| 1.0 mg/kg BD 1063, t = 3.42, p ≤ 0.009 | |||||
| 1.0 mg/kg MPD and BD 1008 | F4,60 = 8.54, p < 0.001 | F3,60 = 8.06, p = 0.002 | F12,60 = 7.27, p < 0.001 | 3.2 mg/kg BD 1008, t = 3.15, p ≤ 0.016 | 3.2 mg/kg BD 1008, t = 4.54, p < 0.001 |
| 10 mg/kg BD 1008, t = 4.37, p ≤ 0.016 | 10 mg/kg BD 1008, t = 6.62, p < 0.001 | ||||
| 1.0 mg/kg MPD and BD 1047 | F4,60 = 8.41, p < 0.001 | F3,60 = 8.98, p = 0.001 | F12,60 = 7.10, p < 0.001 | 3.2 mg/kg BD 1047, t = 4.44, p < 0.001 | 3.2 mg/kg BD 1047, t = 5.99, p < 0.001 |
| 10 mg/kg BD 1047, t = 4.31, p < 0.001 | 10 mg/kg BD 1047, t = 7.02, p < 0.001 | ||||
| 1.0 mg/kg MPD and BD 1063 | F4,60 = 8.99, p < 0.001 | F3,60 = 8.77, p = 0.001 | F12,60 = 7.56, p < 0.001 | 3.2 mg/kg BD 1063, t = 4.24, p < 0.001 | 3.2 mg/kg BD 1063, t = 5.64, p < 0.001 |
| 10 mg/kg BD 1063, t = 4.37, p < 0.001 | 10 mg/kg BD 1063, t = 6.99, p < 0.001 | ||||
| 0.32 mg/kg nomifensine and BD 1008 | F4,60 = 14.7, p < 0.001 | F3,60 = 13.7, p < 0.001 | F12,60 = 12.8, p < 0.001 | 3.2 mg/kg BD 1008, t = 6.11, p < 0.001 | 3.2 mg/kg BD 1008, t = 7.35, p < 0.001 |
| 10 mg/kg BD 1008, t = 5.91, p < 0.001 | 10 mg/kg BD 1008, t = 9.00, p < 0.001 | ||||
| 0.32 mg/kg nomifensine and BD 1047 | F4,60 = 13.3, p < 0.001 | F3,60 = 12.9, p = 0.001 | F12,60 = 11.8, p < 0.001 | 3.2 mg/kg BD 1047, t = 4.63, p < 0.001 | 3.2 mg/kg BD 1047, t = 5.26, p < 0.001 |
| 10 mg/kg BD 1047, t = 5.77, p < 0.001 | 10 mg/kg BD 1047, t = 8.26, p < 0.001 | ||||
| 0.32 mg/kg nomifensine and BD 1063 | F4,60 = 16.3, p < 0.001 | F3,60 = 14.9, p = 0.001 | F12,60 = 13.3, p < 0.001 | 3.2 mg/kg BD 1063, t = 6.19, p < 0.001 | 3.2 mg/kg BD 1063, t = 7.31, p < 0.001 |
| 10 mg/kg BD 1063, t = 6.30, p < 0.001 | 10 mg/kg BD 1063, t = 9.22, p < 0.001 | ||||
N.S., not significant.