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Time-dependent increases in cGMP content in VSMCs stimulated with BAY (10 μM). The levels of cGMP peaked at 20 min after BAY treatment, reaching levels ∼250 times over that of vehicle-treated cells. These levels of cGMP persisted through 60 min (∼140×) compared with controls. No differences between BAY and vehicle groups were observed for cAMP levels at any time point ≤60 min (data not shown). Data are mean ± S.E.M. from two independent experiments performed in duplicate.
