Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Nov;339(2):451–463. doi: 10.1124/jpet.111.180505

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

U.S. Government work not protected by U.S. copyright

PMC Copyright notice

Fig. 4. — 11,12-EET suppression of ATO-induced p38 and JNK activation. Cells were starved overnight, preincubated with 11,12-EET or p38/JNK inhibitor for 12 h, and incubated with ATO or H₂O₂ for 15 min. Data are representative of three independent experiments. Results shown are mean ± S.E.M. (n = 3). A and B, p38 and JNK activation in Tca-8113 cells treated with ATO (10 μM), 11,12-EET (100 nM), and H₂O₂ (200 μM) as indicated. C and D, flow cytometric analysis of Tca-8113 cells treated with p38 inhibitor (20 μM) as indicated for 24 h using Annexin V-FITC and PI staining. E and F, flow cytometric analysis of Tca-8113 cells treated with JNK inhibitor (50 μM) as indicated for 24 h using Annexin V-FITC and PI staining. *, p < 0.05 versus control; **, p < 0.05 versus ATO; #, p < 0.05 versus ATO+EET or ATO+p38/JNK Inhibitor.

Fig. 4. — 11,12-EET suppression of ATO-induced p38 and JNK activation. Cells were starved overnight, preincubated with 11,12-EET or p38/JNK inhibitor for 12 h, and incubated with ATO or H₂O₂ for 15 min. Data are representative of three independent experiments. Results shown are mean ± S.E.M. (n = 3). A and B, p38 and JNK activation in Tca-8113 cells treated with ATO (10 μM), 11,12-EET (100 nM), and H₂O₂ (200 μM) as indicated. C and D, flow cytometric analysis of Tca-8113 cells treated with p38 inhibitor (20 μM) as indicated for 24 h using Annexin V-FITC and PI staining. E and F, flow cytometric analysis of Tca-8113 cells treated with JNK inhibitor (50 μM) as indicated for 24 h using Annexin V-FITC and PI staining. *, p < 0.05 versus control; **, p < 0.05 versus ATO; #, p < 0.05 versus ATO+EET or ATO+p38/JNK Inhibitor.