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. Author manuscript; available in PMC: 2011 Oct 24.
Published in final edited form as: Neuroscientist. 2011 Feb 10;17(5):475–492. doi: 10.1177/1073858410390378

Figure 5. Enzymes catalyzing the palmitoylation and de-palmitoylation of htt.

Figure 5

(a) Protein acyl transferases (PATs) HIP14 and its closely related family member, HIP14L, catalyse the addition of palmitate (palm) to htt at cysteine 214 via a thioester bond . Removal of palmitate is carried out by an unidentified thioesterase. Reduced palmitoylation can result in altered protein trafficking leading to protein aggregation and synaptic dysfunction. (b) Potential therapeutic targets related to palmitoylation of htt are highlighted.