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Laccase activity (units mg-1 total secreted protein) in culture supernatants of A. niger N593 transformants expressing McoA with its native secretion signal (ssMcoA) (white bars) and with ssMcoA replaced by the glucoamylase leader sequence (ssGlaA) (grey bars). The embedded table shows the average (Av.), the average of the five best producers (Av. TOP 5), the median and the higher levels (Max.) of McoA secreted by each group of transformants.
