Table 3.

Study outcomes and measures

Variable	Measure	Source
Primary Effectiveness Outcomes
Appropriate breast cancer screening	Risk-based guideline screening performed	Genetic counselor pedigree and chart review
Appropriate ovarian cancer screening	Risk-based guideline screening performed	Genetic counselor pedigree and chart review
Appropriate colon cancer screening	Risk-based guideline screening performed	Genetic counselor pedigree and chart review
Appropriate hereditary thrombophilia testing	Risk-based guideline screening performed	Genetic counselor pedigree and chart review
Secondary Effectiveness Outcomes
Patient health-related behaviors	Diet Exercise Smoking status Intention to obtain cancer screening Knowledge about genetic testing	HINTS[16] given at baseline, 3 month and 12 months
Provider care patterns	Orders for: Screening studies Referrals to GC Genetic testing Documentation of: Disease risk MeTree recommendations	Chart review
MeTree operating characteristics	Sensitivity and specificity Net Reclassification Number needed to treat to identify high risk Subgroups affected by reclassification	Pedigree review by GC Pedigree review by PCP
Costs	Referrals, office visits, procedures, testing	Chart review
Implementation Outcomes
Patient experience	Satisfaction Preparedness Ease of use Level of anxiety Time to use Questions\resource needs	Post-MeTree survey MeTree Study Coordinator
Provider experience	Agreement with recommendations Does it change practice Recommend it to peers Quality and usefulness of reports Impact on patient flow Time spent discussing MeTree reports	Provider survey and interviews
Clinic needs	Resource needs to implement Assistance required for patients/providers Training/time required for clinic staff	Study coordinators Interviews
Covariates
Demographics	Age Gender Ethnicity	MeTree input
Education level		Baseline survey
Insurance		Baseline survey
Family	Size % with cancer	MeTree input
BMI		Measured at triage
Clinic
Provider	Year of medical school graduation Gender	Provider survey

GC = genetic counselor; PCP = primary care provider