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Analogues generated for determination of active sub-structures.
| Structure | D10 strain IC50 (μM) n = 2 |
K1 strain IC50 (μM) n = 2 |
CHO IC50 (μM) n = 2 |
|---|---|---|---|
 |
1.865* | 4.095# | 17.2 |
 |
11.5 | 9.05 | 7.01 |
 |
> 40 | NT | > 400 |
 |
> 40 | NT | > 400 |
 |
22.1 | NT | 124 |
 |
16.9 | NT | 41.9 |
n = number of technical replicates averaged - each independent experiment performed in duplicate with several independent experiments performed for the parent compound dehydrobrachylaenolide
* n = 8
# n = 4
