Table 2.

Summary of seminal vesicle secretory proteins identified in mouse SVS.

			Expression
Protein	Function	Reference	Mass	Western	Cancer-related studies
Upregulated expression
Sulfhydryl oxidase 1	Catalyze disulfide bond formation	[25]	⇑	⇑	[26, 27]
Glia-derived nexin	Serine protease inhibitor	[8]	⇑	⇑	[28, 29]
Seminal vesicle secretory protein 1	Amine oxidase activity/Copulatory plug formation	[5]	⇑	⇑	—
Seminal vesicle secretory protein 3a	Copulatory plug formation	[19]	⇑	⇑	—
Seminal vesicle secretory protein 3β	Copulatory plug formation	[30]	⇑	⇑	—
Seminal vesicle secretory protein 6	Serine proteinase inhibitor	[31]	⇑	—	[32]
Downregulated expression
Seminal vesicle secretory protein 2	Semen-coagulating protein/Sperm decapacitation factor	[6, 33]	⇓	⇓	[34]
Carcinoembryonic antigen-related cell  adhesion molecule 10	Sperm binding and enhancement of sperm motility	[7]	⇓	⇓	—
Lysozyme C, type M	Primary bacteriolysis	—	⇓	⇓	—
Seminal vesicle secretory protein 5	Serine proteinase inhibitor	[35]	⇓	⇓	—
Secreted seminal-vesicle Ly-6 protein 1	Potential cellular adhesion and signaling	[21]	⇔	⇓	—
Seminal vesicle secretory protein 7	Sperm capacitation factor	[20]	⇓	⇓	—
Serine protease inhibitor kazal-like  protein	Serine protease inhibitor/Sperm decapacitation factor	[22]	⇓	⇓	—
Serine protease inhibitor Kazal-type 3	Serine protease inhibitor/Sperm decapacitation factor	[9]	⇓	⇓	—
Seminal vesicle antigen	Sperm decapacitation factor	[36]	⇓	—	—
Seminal vesicle secretory protein 4	Anti-inflammatory and immune-modulating agent	[37]	⇔	—	—