Skip to main content
. 2011 Aug 11;96(10):3207–3216. doi: 10.1210/jc.2011-0480

Table 2.

Plasma concentration of inflammatory and oxidative stress markers after 24 h administration of PN containing soybean oil-based lipid emulsion, olive oil-based lipid emulsion, lipid-free PN, and normal saline in healthy subjects

Variable 0 h 12 h 24 h P valuea
CRP (mg/liter) 0.198
    Saline 3.88 ± 3.34 3.89 ± 2.63 4.41 ± 2.87
    Lipid free 5.91 ± 5.58 5.73 ± 4.17 4.59 ± 3.77
    Soybean oil based 3.94 ± 2.85 5.15 ± 4.18 4.35 ± 3.07
    Olive oil based 4.03 ± 2.73 5.64 ± 3.39 5.59 ± 3.64
TNF-α (pg/ml) 0.422
    Saline 10.50 ± 4.71 10.29 ± 4.24 10.99 ± 4.36
    Lipid free 12.25 ± 5.01 13.83 ± 5.99 11.83 ± 4.21
    Soybean oil based 11.5 ± 4.51 13.01 ± 5.63 12.06 ± 5.59
    Olive oil based 10.01 ± 3.67 10.16 ± 3.67 11.14 ± 4.72
IL-6 (pg/ml) 0.795
    Saline 2.45 ± 0.62 9.11 ± 3.94 6.06 ± 5.58
    Lipid free 3.13 ± 1.70 8.2 ± 5.58 5.11 ± 2.25
    Soybean oil based 2.61 ± 1.12 8.52 ± 3.71 6.54 ± 4.44
    Olive oil based 2.76 ± 0.69 6.36 ± 2.67 5.59 ± 2.69
Cystine (μm) 0.978
    Saline 66.46 ± 17.50 66.69 ± 10.52 69.01 ± 14.23
    Lipid free 75.26 ± 23.71 81.31 ± 20.67 78.95 ± 15.06
    Soybean oil based 70.08 ± 22.62 77.99 ± 18.74 72.48 ± 15.16
    Olive oil based 76.60 ± 25.90 81.26 ± 19.79 80.97 ± 19.79
Cysteine (μm) 0.101
    Saline 8.99 ± 2.60 8.34 ± 2.66 8.29 ± 1.95
    Lipid free 9.42 ± 2.78 10.35 ± 3.35 9.81 ± 2.85
    Soybean oil based 7.89 ± 2.92 9.33 ± 3.57 8.28 ± 1.66
    Olive oil based 8.26 ± 2.86 10.18 ± 2.93 8.78 ± 2.85
Cysteine-glutathione disulfide (μm) 0.338
    Saline 1.77 ± 0.74 2.24 ± 1.36 1.82 ± 0.95
    Lipid free 2.10 ± 0.99 1.40 ± 0.66 1.75 ± 0.83
    Soybean oil based 1.96 ± 0.83 1.63 ± 0.62 1.38 ± 0.45
    Olive oil based 1.97 ± 0.97 1.64 ± 0.65 1.79 ± 0.89
Glutathione (μm) 0.374
    Saline 1.13 ± 0.83 1.10 ± 1.01 0.88 ± 0.42
    Lipid free 1.01 ± 0.80 0.62 ± 0.33 0.73 ± 0.38
    Soybean oil based 0.88 ± 0.64 0.73 ± 0.47 0.75 ± 0.29
    Olive oil based 0.74 ± 0.29 0.84 ± 0.71 0.78 ± 0.49
Glutathione disulfide (μm) 0.387
    Saline 0.04 ± 0.03 0.04 ± 0.05 0.03 ± 0.04
    Lipid free 0.06 ± 0.08 0.03 ± 0.02 0.05 ± 0.06
    Soybean oil based 0.04 ± 0.03 0.04 ± 0.05 0.04 ± 0.03
    Olive oil based 0.03 ± 0.01 0.13 ± 0.30 0.05 ± 0.04
Glutathione redox potential (μm) 0.021
    Saline −129.13 ± 20.42 −125.78 ± 23.59 −129.09 ± 12.51
    Lipid free −122.75 ± 13.58 −121.30 ± 14.34 −118.03 ± 15.08
    Soybean oil based −117.12 ± 36.97 −114.56 ± 27.39 −121.90 ± 16.22
    Olive oil based −120.23 ± 12.07 −119.09 ± 20.32 −116.03 ± 17.17
Cysteine redox potential (μm) 0.051
    Saline −72.08 ± 7.42 −68.50 ± 13.79 −68.73 ± 7.20
    Lipid free −71.20 ± 7.41 −72.20 ± 8.79 −71.73 ± 8.34
    Soybean oil based −67.00 ± 11.78 −69.20 ± 14.41 −69.06 ± 7.20
    Olive oil based −67.87 ± 8.91 −72.54 ± 6.87 −69.27 ± 7.45
Total glutathione, sum of glutathione + 2* glutathione disulfide + cysteine-glutathione disulfide (μm) 0.565
    Saline 2.97 ± 1.54 3.43 ± 2.41 2.76 ± 1.40
    Lipid free 3.24 ± 1.55 2.05 ± 0.89 2.63 ± 1.17
    Soybean oil based 2.88 ± 1.15 2.46 ± 1.08 2.17 ± 0.64
    Olive oil based 2.77 ± 1.13 2.55 ± 1.22 2.66 ± 1.25
Total cysteine, sum of cysteine + 2*cystine + cysteine-glutathione disulfide (μm) 0.983
    Saline 143.74 ± 36.23 143.93 ± 21.94 148.12 ± 29.15
    Lipid free 162.05 ± 50.21 170.62 ± 43.32 169.47 ± 3098
    Soybean oil based 150.03 ± 46.17 166.91 ± 38.34 154.58 ± 29.83
    Olive oil based 163.43 ± 52.90 174.34 ± 41.09 172.50 ± 40.95
a

P value for comparing the changing trend of each variable across time points (0, 4, 24 h) among the four infusion groups based on repeated-measures ANOVA models.