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Conventional PCa (Gleason 4 + 4 = 8) detected in a needle biopsy. Chromogranin A (CGA) immunohistochemistry reveals extensive neuroendocrine (NE) differentiation, which presents a multidrug-resistant phenotype in PCa (a). Immunohistochemical detection of somatostatin receptors in NE PCa cells (b) provides a therapeutic target for somatostatin analogues. Original magnifications: (a) (×100), (b) (×300).
