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Helical wheel projection of the original and variant peptides studied. The colors reflect the hydrophobicities according to the Wimley-White interfacial scale (18). White, hydrophilic or neutral; light gray, hydrophobic; magenta, aromatic; red, negatively charged; and blue, positively charged, at pH 7.5. The only difference between DL-2a and DL-2b is the replacement of Ala 13 and 23 by Leu in DL-2b.
