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Animals were treated 24 hours prior to infection with a single i.n. instillation of the indicated dose of DEF201, the rAd EV control virus, or PBS placebo. (A) Survivial and (B) average weights and standard deviations of surviving animals (measured every 3rd day) are shown. ***P<0.001 compared to placebo-treated animals. b P<0.01 and c P<0.001 compared to rAd EV-treated animals.
