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. 2011 Oct 24;6(10):e26072. doi: 10.1371/journal.pone.0026072

Figure 3. DEF201 extended pre-exposure prophylaxis protects hamsters from lethal PICV challenge.

Figure 3

Animals were treated i.n. with a single dose 108 pfu of DEF201, the rAd EV control virus, or PBS placebo 7 or 14 days prior to PICV infection. Animal weights were measured two weeks prior to, and at the time of, PICV challenge. The effect of 7-day and 14-day pretreatments on A) weight change over the two-week period prior to PICV challenge and the extended PICV prophylaxis efficacy data for the B) 7-day and C) 14-day pretreatments are shown. ***P<0.001 compared to respective placebo-treated animals. b P<0.01, c P<0.001 compared to respective rAd EV-treated animals.