Figure 5. Early DEF201 post-exposure-treatment protects PICV-infected hamsters from mortality.

Animals were treated with a single i.n. dose of 10⁸ pfu of DEF201 or the rAd EV control 24 h prior to infection, or 6, 24, or 48 h post infection. The dashed lines represent the 1^st and 2^nd challenges of the animals with PICV on day 0 and 28 of the experiment, respectively. For the initial infection, **P<0.01, ***P<0.001 compared to respective rAd EV-treated controls. For the second infection, sham-infected animals from the 1^st infection were challenged with PICV and compared to groups of surviving animals; ^a P<0.05, ^b P<0.01, ^c P<0.001.