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. 2011 Oct 24;6(10):e26615. doi: 10.1371/journal.pone.0026615

Figure 7. In vivo effect of phenethyl isothiocyanate on expression of cleaved Notch2 protein in prostate tumor.

Figure 7

(A) Representative H&E staining and immunohistochemical staining for expression of cleaved Notch2 protein in PC-3 xenografts from three mice of the indicated groups (scale bar, 50 µm; magnification, 400×). Amplification of selected area is shown in the inset. Quantitation of nuclear expression of Notch2 protein in PC-3 xenografts from control and phenethyl isothiocyanate (PEITC)-treated mice is shown in the bar graph (mean ± SD; n = 3). (B) Immunohistochemistry showing cleaved Notch2 protein expression in the dorsolateral prostates from four TRAMP mice of the indicated groups (scale bar, 50 µm; magnification, 400×). Amplification of selected area is shown in the inset. Quantitation of nuclear expression of cleaved Notch2 protein in the dorsolateral prostates of control and PEITC-fed TRAMP mice is shown in the bar graph (mean ± SD; n = 4). Statistical significance was determined by Student's t-test.