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. 2011 Oct 24;6(10):e26647. doi: 10.1371/journal.pone.0026647

Figure 5. Effects of Forskolin treatment on WT and mutated CRH promoter activity.

Figure 5

Luciferase activity was measured in IVB cell line after treatment with 25 µM Forskolin for 6.0 h (black bars) or vehicle (white bars) in WT CRH promoter or mutated promoter lacking GR binding site 1 (CRHΔGR1), GR binding site 2 (CRHΔGR2) or GR binding site 1 and 2 (CRHΔGR1/2). Data expressed as % change in luciferase activity of vehicle treated control. Dissimilar letters indicate statistically significant difference (P<0.05).