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. 2011 Oct 24;6(10):e26626. doi: 10.1371/journal.pone.0026626

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Humphries et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Confocal microscopy image of ECFP-Rab7 (blue), EYFP-LAMP1 (green), and dextran-AF647 (red) after an 18 h incubation with dextran. The inset, split into its three color components and enlarged, shows a Rab7-vesicle in the absence of dextran and a LAMP1-vesicle containing dextran, both circled. (B) At early times dextran is present in Rab7- (blue), LAMP1- (green), and Rab7/LAMP1-vesicles (black). At longer times the percentage of Rab7-vesicles containing dextran decreases while the percentage of LAMP1- and Rab7/LAMP1-vesicles increase. The x-axis is plotted to highlight the early time data. Error bars represent standard deviation. At each time point, analysis was carried out for 10-15 vesicles per cell in 6–12 cells in 2–4 distinct experiments.